The Mokolo River is a major watercourse in Limpopo Province of South Africa.

[2] The Mokolo River and its upper course tributaries rise in the southwestern part of the Waterberg, between 1200 and 1600 metres above mean sea level.

[3] As it heads northwards it threads through the northern Waterberg, an extensive rock formation that was shaped by hundreds of millions of years of river erosion to yield diverse bluffs and buttes.

From this point, the Mokolo River flows through flat sandy areas until it reaches the Limpopo's right bank.

Some wetlands rehabilitation in the upper Mokolo has been carried out and that effort has been deemed a success.