Molly, whose given name is Marion, was born in Gibraltar on 8 September 1870, the daughter of Major Tweedy, an Irish military officer, and Lunita Laredo, a Gibraltarian of Spanish descent.

The final chapter of Ulysses, often called "Molly Bloom's Soliloquy", is a long and almost entirely unpunctuated passage comprising her thoughts as she lies in bed next to Leopold.

When written this episode contained the longest "sentence" in English literature, 4,391 words expressed by Molly Bloom (it was surpassed in 2001 by Jonathan Coe's The Rotters' Club).

[4] Some research also points to another possible model for Molly in Amalia Popper, one of Joyce's students to whom he taught English while living in Trieste.

The character Ralph Spoilsport recites the end of the soliloquy, with erratic variations in gender pronouns, as the last lines of the Firesign Theatre's album How Can You Be in Two Places at Once When You're Not Anywhere at All.