The restaurant's name and premise are inspired by a line from his song "Lose Yourself" from the soundtrack to the 2002 movie 8 Mile, in which he says "There's vomit on his sweater already, mom's spaghetti."

The restaurant also contains a merchandise shop, The Trailer, that houses the Robin suit from the music video of the single "Without Me".

[12] A telephone number ((313)-888-8388) flashed on the bottom of the screen, which, when called, added that there would be a merchandise store on the restaurant's second floor.

[1][14][15][16] A temporary Mom's Spaghetti location at 820 S. Spring St. was opened in Los Angeles for Super Bowl LVI, from February 9 to 13.

[22] During Eminem's collaboration with the online video game Fortnite in late 2023, a Mom's Spaghetti cosmetic item was available.

[23] In addition, another Fortnite collaboration added a location inspired by the restaurant, complete with new cosmetic items and a themed weapon.