Handley's short-tailed opossum (Monodelphis handleyi) is a species of mammal in the family Didelphidae.

The species is named after Charles O. Handley, Jr. to honor his contribution to the study of neotropical mammals.

It has short dorsal fur with the hair having pale gray bases and brown tips.

The height of the tree canopy was 25-30 meters with a dense understory and abundant palms.

There is lack of information about the animals habitat requirement, population, and habits, although probable threats include selective logging and deforestation in its range.