[1] The Pebas four-eyed opossum was described in 2018 by Robert S. Voss, Juan F. Díaz-Nieto, and Sharon Jansa.

[2] Eastern and western populations showed some genetic variation, but not enough to warrant subspecific status.

The stomach fur is mostly grayish with some cream or buffy colors along the base of the legs and bottom of the jaw.

One specimen collected in 1989 was less than 35 km (22 mi) from Bolivia, but this species is not officially known from that country; it may also occur in Colombia.

[1] Similar to its congeners, this species is likely a true omnivore, consuming invertebrates, small vertebrates, fruits, nectar, carrion, and some cereals.

[4] When the habitat of this species is flooded it either flees to higher grounds, climbs to the upper canopy, or a combination of both of these.