Monroe Creek begins in a pond or small lake in Springville Township, Susquehanna County.

The creek then turns south for more than a mile, passing through another wetland and entering Nicholson Township, Wyoming County.

It then turns south for several tenths of a mile, leaves its valley, crosses Pennsylvania Route 92, and reaches its confluence with Tunkhannock Creek.

[5] Further upstream, the surficial geology is fairly similar, but there is a patch of alluvial fan and a wetland near the creek just north of the Susquehanna County line.

In the creek's upper reaches, the surficial geology consists of Wisconsinan Till, except for a wetland at the headwaters.

[4] This variant name appears in Israel C. White's 1883 book The geology of the North Branch Susquehanna River Region in the six counties of Wyoming, Lackawanna, Luzerne, Columbia, Montour and Northumberland.

[8] A concrete tee beam bridge carrying Pennsylvania Route 92 over Monroe Creek was built in Nicholson Township, Wyoming County in 1931 and is 30.8 feet (9.4 m) long.