[1][2] The show critically examines the science behind cryptozoological creatures, such as Bigfoot, the Loch Ness Monster, and werewolves.

[4] The first episode was released on July 2, 2009, and featured an interview with NYU Professor Todd Disotell about the attempted use of DNA evidence in cryptozoologists' search for Bigfoot.

The show has covered an extensive array of monsters and cryptids, including zombies,[6] demons,[7][8] ninjas,[9] the Mothman,[10] Cthulhu,[11] the Skookum cast,[12] the Patterson–Gimlin film,[13] the Minnesota Iceman,[14] the Chupacabra;[2] and extinct animals such as pterosaurs,[15] plesiosaurs,[16] and the thylacine.

[17] Guests of the show have included Phil Plait,[18] Professor PZ Myers,[11] Steven Novella,[19] magician James Randi,[20] author Brian Regal,[21] writer and illustrator Daniel Loxton,[22] and investigator Joe Nickell.

[10] In 2011, Curt Holman conducted an interview with MonsterTalk's producer, Blake Smith, for an article in Creative Loafing.