In the Middle Ages, this street was still a country path already taken during the prehistoric times, bordered by agricultural land, including vineyards.

The nuns of the desert bought the western part in 1296 and decided to change the route in a street several centuries later.

Then, from the 16th century, it became a major axis of entry and exit from the Presqu'île by the North since the Porte Saint-Sébastien or La Croix-Rousse.

[4] In 1628, a small statue of Saint-Roch and a plaque in Latin, installed to indicate where the plague epidemic stopped, were added and finally removed after the French Revolution.

[5] While the rest of the plateau and slopes of La Croix-Rousse were mainly composed of religious congregations, the Grand'Côte already hosted many canuts.

The Grand'Côte became the crossing place of the workers who came down to Lyon, to the Capuchins, the district of merchants or Condition des soies).

From 1854 to 1930, the Rue des Pierres Plantées was incorporated to the Montée de la Grande Côte.