However, the zone was constantly controlled, as the Ponte Nomentano bridge was a relevant outpost and an important crossing point toward the northern Latium.

Construction started in the area in the 1920s, when architect Gustavo Giovannoni planned and built a new borough, inspired by the principles of the Garden city movement.

The commitment of the locals to the Resistenza during the Nazi occupation has been very remarkable, and two residents of Monte Sacro, the partisans Ferdinando Agnini and Orlando Orlandi Posti, were killed in the Ardeatine massacre.

To the east, Monte Sacro also borders with Quartiere XXIX Ponte Mammolo, whose boundary runs in the countryside from Via Nomentana up to the river Aniene.

To the south-west, the quarter borders also with Q. XVII Trieste, whose boundary is marked by Circonvallazione Salaria and then runs along the river Aniene, up to the bridge of the FL1 regional railway.