The company was founded by Joe Lezak, whose family had a long history of selling meat products in Chicago.
Moo & Oink sold a variety of meats including pork, chicken, beef, and lamb.
In the 1960s, the company moved to a larger location at 3831 S. Halsted Avenue in Bridgeport, Chicago.
In 2005, Tina Fey and Amy Poehler sang the opening verse of the jingle on Saturday Night Live's Weekend Update in order to prove to Scott Podsednik that they were Chicago White Sox fans.
In April 2010, the remaining owners revealed a new company logo with updated art of the cow and pig characters.