He won the World Series with the 2005 Chicago White Sox, hitting a walk-off home run in Game 2.

He signed with the Seattle Mariners as a minor league free agent and was placed at the Triple-A level with the Tacoma Rainiers.

[1] He made his Major League debut on July 6, 2001, against the Los Angeles Dodgers, pinch-running for Ichiro Suzuki.

In his first career major league at-bat, against the Arizona Diamondbacks on July 15, he hit a bases loaded triple.

[4] In 2002, Podsednik played mostly at Triple-A Tacoma, but was activated for 14 Major League games, hitting his first major-league home run during that time.

While only inserted permanently into the starting lineup in mid-May, Podsednik still finished second to the Florida Marlins' Dontrelle Willis in the official Rookie of the Year balloting.

In December 2004, Podsednik was dealt to the Chicago White Sox (along with Travis Hinton and Luis Vizcaíno) for Carlos Lee.

On April 14, 2009, Podsednik agreed to return to the White Sox on a minor-league deal, assigning him to the AAA Charlotte Knights.

On July 28, 2010, the Royals traded Podsednik to the Los Angeles Dodgers in return for two minor league players, catcher Lucas May and pitcher Elisaul Pimentel.

He played for the Las Vegas 51s in the Pacific Coast League as a member of the Toronto Blue Jays organization.

[11] He was assigned to their Triple-A affiliate, the Lehigh Valley IronPigs, but was limited to playing in just 14 games due to injuries.

On May 22, 2012 he made his debut, pinch hitting for Marlon Byrd in the seventh inning of a game against the Baltimore Orioles.

On July 31, 2012, Podsednik was traded to the Arizona Diamondbacks, along with RHP Matt Albers, for LHP Craig Breslow.