It serves the northern suburb of Moonee Ponds in Melbourne, Victoria, Australia.

The station closed with the line on 1 July 1864, but was reopened on 9 October 1871, under government ownership.

[5] Like the suburb itself, the station is believed to have gotten its name from either the Moonee Ponds Creek, which resembled a chain of ponds in dry weather (the creek was noted as "Mone Mone Creek" in 1837 by government surveyor Robert Hoddle, during a survey of the area), an Indigenous Australian who was attached to the mounted police, or John Moonee, who had land near the present day Moonee Valley Racecourse.

[5] On 4 May 2010, as part of the 2010/2011 State Budget, $83.7 million was allocated to upgrade Moonee Ponds to a premium station, along with nineteen others.

[11] Platform 1: Platform 2: Ryan Brothers Bus Service operates one route to and from Moonee Ponds station, under contract to Public Transport Victoria: Moonee Ponds Junction is located 400 metres east of the station, and is the terminus for routes operated by CDC Melbourne, Dysons, Kastoria Bus Lines and Transit Systems Victoria.