Anatomical pathology

Over the 20th century, surgical pathology has evolved tremendously: from historical examination of whole bodies (autopsy) to a more modernized practice, centered on the diagnosis and prognosis of cancer to guide treatment decision-making in oncology.

Cytopathology is a sub-discipline of anatomical pathology concerned with the microscopic examination of whole, individual cells obtained from exfoliation or fine-needle aspirates.

Cytopathologists are trained to perform fine-needle aspirates of superficially located organs, masses, or cysts and are often able to render an immediate diagnosis in the presence of the patient and consulting physician.

Cytopathology is a board-certifiable subspecialty in the U.S. Molecular pathology is an emerging discipline within anatomical and clinical pathology that is focused on the use of nucleic acid-based techniques such as in-situ hybridization, reverse-transcriptase polymerase chain reaction, and nucleic acid microarrays for specialized studies of disease in tissues and cells.

Anatomical Pathology (AP) is one of the specialist certificates granted by the Royal College of Physicians and Surgeons of Canada.

After completing residency, many pathologists enroll in further years of fellowship training to gain expertise in a subspecialty of AP or CP.

To become a Pathologists' Assistant one must enter and successfully complete a NAACLS accredited program and pass the ASCP Board of Certification Exam.

Histopathology : microscopic appearance of invasive ductal carcinoma of the breast. The slide is stained with Haematoxylin & Eosin.
Histopathology : microscopic appearance of invasive ductal carcinoma of the breast. The slide is stained with an antibody ( immunohistochemistry ) against the oncogene Her2neu . The dark-brown reaction indicates that this tumor over-expresses this gene.
Cytopathology : microscopic appearance of a Pap test . The pink cell at the center with a large nucleus is abnormal, compatible with low-grade dysplasia .
Autopsy : a brain surrounded by pus (the yellow-greyish coat around the brain, under the dura lifted by the forceps), the result of bacterial meningitis .
Gross examination : appearance of the cut surface of a lung showing the honeycomb pattern of end-stage pulmonary fibrosis .
Gross examination : appearance of a colorectal polyp (the cauliflower-shaped tumor) attached to the colon mucosa (the horizontal line at the bottom).