The station was opened by the Oxford, Worcester and Wolverhampton Railway (OWW) on 4 June 1853,[2] the day that the southern section of the OWW's main line, between Evesham and Wolvercote Junction (just north of Oxford), was opened.

[4] Reduplication of the line was completed in 2011, and Moreton-in-Marsh is once again a station on normal double track, with two side platforms.

Between 2000 and 2010, the station was the base of Cotswold Rail, a spot-hire company for shunting and mainline locomotives, which went into liquidation.

That is for the benefit of tourists because Japanese television promotes the Cotswolds as a holiday destination.

The typical off-peak service in trains per hour is: The station was used in the filming of the BBC2 situation comedy, Butterflies.