[2] Other signs and symptoms include headaches, vertigo, hirsutism, menstrual disorder, galactorrhoea, obesity, depression, and seizures.

[2] It is characterized by a thickening of the inner table of the frontal part of the skull, a usually benign condition known as hyperostosis frontalis interna.

[3] It is named after the Italian anatomist and pathologist Giovanni Battista Morgagni, the British neurologist Roy Mackenzie Stewart, and the Swiss psychiatrist Ferdinand Morel.

Diagnosis considers a combination of clinical features including obesity,[4] virilism, and mental disturbances.

[5] Treatment is based upon the symptoms, and generally includes medication, diet and lifestyle modification for weight control.