Morosina Morosini-Grimani was the daughter of Andrea Morosini, a wealthy Venetian patrician.

With her spouse's election as doge in 1595, her own coronation as official dogaressa consort was conducted with enormous pomp and ceremony in May 1597.

The ceremony was conducted with the purpose of surpassing all previous seen in Venice, and celebrated with processions of gondolas, banquets for foreign princes and ambassadors and dignitaries of the church, and the dogaressa was given the Golden Rose by the Papal envoy.

She became the patron of the famous lace-making industry at Burano, and established a committee to promote and popularize the craft among the upper class women of Venice.

She did not follow the tradition that the dowager dogaressa should enter a convent, but devoted herself to charitable and devout projects.