It purchased 39 acres of land at Riverside Road and Faraon Street and hired the architecture and engineering firm Henningson, Durham, and Richardson to oversee the construction of the new hospital.

By 1983, Missouri Methodist Medical Center and St. Joseph Hospital had agreed to combine into a single organization and form Heartland Health Affiliates.

[4][9] In May 2012, the hospital joined the Mayo Clinic Care Network, expanding its healthcare partnerships.

[10] In June of that same year, the Heartland Health System announced it would begin the transition to a new name: Mosaic Life Care.

[13] The University of Missouri–Kansas City School of Medicine opened a satellite campus located at the hospital in January 2021.