[6] Moschino studied at Accademia di Belle Arti in Milan from 1968 to 1971, at the dismay of his father, who hoped Franco would continue his family's work in the iron industry.

[6] By the late 1980s, Moschino's popularity in Europe had begun to replicate in the United States, with US sales accounting for 15 to 20 percent of business.

[10] In recent times, Moschino has made an effort to combat the HIV/AIDS epidemic through a partnership with Product Red and Nickelodeon, creating a Moschino x SpongeBob collection, bringing awareness to HIV/AIDS and fundraising by donating the collection's proceeds to Project Red.

[27] In October 2023, Aeffe announced Davide Renne as the new creative director of Moschino, overseeing the women's and men's lines and accessories.

[28][29] He assumed the role on 1 November, but died from a suspected heart attack in Milan nine days later, at the age of 46.

[30] Prior to his appointment, Appiolaza worked at Loewe for 10 years as womenswear design director under Jonathan Anderson.

[34] In a 2015 lawsuit, New York-based graffiti artist Rime claimed the Moschino dress worn by Katy Perry at the 2015 Met Gala copied his work.

[36] In 2016, Nordstrom responded to pressure from consumers and pulled Moschino's pill-themed merchandise from its shelves, amid allegations it trivialized the opioid epidemic.