In 1627 he married Dobrusch, a daughter of Isaac ben Phœbus, of Ungarisch-Brod, Moravia, where he lived supported by his wealthy father-in-law.
The Thirty Years' War brought about the ruin of his father-in-law's business, and Samson was compelled to accept a rabbinical position in Göding, Moravia, in 1629.
In 1635 he became rabbi of Leipnik, Moravia, and remained there until the capture of the city by the Swedish army in 1643 scattered the congregation and forced him to return to Prague.
After the death of his wife in 1662 he married Feige in 1664, the widow of Moses ha-Kohen Nerol, rabbi of Metz, who died in 1659 and the mother of the famous jewish physician Tobias Cohn.
Of his literary works there exist a number of responsa published in his son's Ḥuṭ ha-Shani, Frankfurt, 1679, and also some religious poems.