The Mosetse River is a natural watercourse in Botswana.

Within the country of Botswana the Mosetse is a source of water to the ephemeral wetlands of the Makgadikgadi Pans, where a number of crustacean species of limited distribution thrive.

[1] More specifically the Mosetse River discharges into Sua Pan, draining parts of eastern Botswana.

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