Located at the intersection of Mosholu Parkway and Jerome Avenue in the Bedford Park and Norwood neighborhoods of the Bronx, it is served by the 4 train at all times.

[9] Mosholu Parkway station opened on April 15, 1918 as part of the final extension of the IRT Jerome Avenue Line from Kingsbridge Road to Woodlawn.

[15] In 2006, work began on a $55 million contract to renovate five stops on the line to bring them into a state of good repair.

As part of the project, station mezzanines were refurbished, electrical upgrades were completed, and platform floors, canopy roofs, and windscreens were replaced.

[18] In May 2018, New York City Transit Authority President Andy Byford announced his plan subway and bus modernization plan, known as Fast Forward, which included making an additional 50 stations compliant with the Americans with Disabilities Act of 1990 during the 2020–2024 Metropolitan Transportation Authority (MTA) Capital Program to allow most riders to have an accessible station every two or three stops.

[21][22][23] In November 2022, the MTA announced that it would award a $965 million contract for the installation of 21 elevators across eight stations,[24] including Mosholu Parkway which will receive 2 brand new elevators (1 street-to-mezzanine-to-northbound platform outside fare control and 1 mezzanine-to-southbound platform inside fare control).

The station has two mezzanines located underneath the platforms, on the north and south sides of Mosholu Parkway between its service roadways.