As a result of Safavid persecution of Sunnis, he sought refuge at the Mughal court where he was received with respect by Emperor Humayun, who also became Lari's student.

Lari declined the offer, which resulted in a break of relations with the Ottoman Shaykh al-Islām, Ebussuud Effendi.

An author of numerous annotations and commentaries, Lari's best-known work is the Mer'ât-al-advâr va merqât-al-akhbâr, a universal history written in Persian which he dedicated to Ottoman Sultan Selim II upon his accession to the throne.

[1] After fulfilling his pilgrimage, he stayed from 1556/7 onwards in Aleppo in Ottoman Syria where he seemingly attempted to set himself up as a merchant.

[1] At some point he moved to the Ottoman capital of Constantinople (now Istanbul, Turkey), where he acquired access to the Shaykh al-Islām, Ebussuud Efendi (Abu 'l-Suʿud).

[2][1] According to the professor of Islamic studies Hanna Sohrweide, he may have deemed the position as a rather unimportant compared to the earlier situation he found himself in at the Mughal court of Humayun.

[1] His Mer'ât-al-advâr va merqât-al-akhbâr however, an abridged universal history written in Persian prose, became famous.

[1][2] A short summary of the content of each book of Lari's Mer'ât-al-advâr va merqât-al-akhbâr (per to the modern historian Sara Nur Yıldız):[3] The very end of the work also includes a biographical section on statesmen, scholars and poets.

[4] The official Ottoman historiographer (waḳʿa-nüwīs), Es'ad Efendi, also translated Lari's work partially in the 19th century.