The municipality borders the localities Bosa and Fontibón of Bogotá in the east, Soacha in the south, Madrid and Funza in the north and Bojacá in the west.

The Muisca were predominantly farmers and traders and their economy was based on the extraction of salt from the northern parts of the Bogotá savanna.

In Mosquera pineapples, avocadoes, guanabanas, ice-cream beans, pitahayas and guayabas were the fruits traded with warmer climates.

[2] Funza, of which Mosquera formed the southern part until 1861, was founded by conquistador Gonzalo Jiménez de Quesada who arrived in the region on April 20, 1537.

Presently, Mosquera is a satellite town of the capital Bogotá and has grown significantly in recent years.