On May 4, 1881, she joined the Canonesses Regular of Ypres, Belgium, at the medieval Abbey of Notre Dame de la Nouvelle Plante, to fulfill her calling.
[2] In the 1880s the abbey received an appeal from a Catholic priest in the city of Mulagumudu, then in the British Raj, for help in administering an orphanage.
With the permission of her superiors she left Belgium, accompanied only by an enthusiastic volunteer novice of the community, and set sail for India.
Though she lacked the understanding and support of the local bishop, Mother Louise and her companion took charge of the orphanage and began to care for the children it housed.
[4] De Meester shared the chores of the small community, teaching the children and caring for the house, as well as carrying out her responsibility for the young Congregation.
Today the Missionary Sisters of the Immaculate Heart of Mary serve in Belgium, Brazil, Burundi, Cameroun, the Caribbean, Congo, Guatemala, Hong Kong, India, Italy, Mongolia, the Philippines, South Africa, Taiwan and the United States.