Moulhoule (Arabic: مول هولة) is a town in the northern Obock region of Djibouti.

It is situated on the west coast of the Red Sea, at its southern entrance.

It is located on the RN-15 National Highway, which connects it to Obock, located some 70 kilometres (43 miles) to the south and is 15 kilometres (9 miles) south of the border with Eritrea.

Moulhoule is located beside the Bab el Mandeb Strait in the north-east of the Republic of Djibouti, 325 km (202 mi) (by road) from Djibouti City.

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