In 2006, the state member Richard Amery announced extensions totalling 10 beds spread throughout various units within the hospital.

In 2012, the NSW Government announced the Blacktown Mount Druitt Hospital Expansion Project Stage 1.

At Mount Druitt Hospital, projects included an expanded Dental Unit with 8 additional dental chairs, a new Urgent Care Centre, main entry refurbishment, new ambulance bay, sterilising facility upgrade and expanded rehabilitation facilities.

[5] On 14 March 2018, NSW Premier Gladys Berejiklian officially opened the new Community Dialysis Centre at Mount Druitt Hospital, marking the completion of the stage 2 hospital expansion which included a new Centre for Addiction Medicine, Pre-Admissions Clinic, expanded Recovery Unit for operating theatres, and a digital theatre.

Nominated for the RAIA National Sir Zelman Cowen Award Awards/83 Architecture Australia December 1983 p6