Mount Saint Joseph plays most of its sports including wrestling, football, rugby, soccer, volleyball, basketball, baseball, lacrosse, ice hockey, mountain biking, water polo and tennis in the Maryland Interscholastic Athletic Association (MIAA) “A” Conference[5] against other Catholic and private schools.

The basketball team competes in both the MIAA and the Baltimore Catholic League.

The basketball team won the Baltimore Catholic League in 2012/13.

There is also a chapter of the National Honor Society, as well as an ACE Mentoring program for aspiring engineers.

The Drama Club partners up with the local Catholic all-girls school, Mount de Sales Academy to perform two shows each year: a play in the fall and a musical in the spring.