Mount Sherrill is flanked to the east by North Dome, and to the west by Balsam Mountain.

Mount Sherrill stands within the watershed of the Hudson River, which drains into New York Bay.

Sherrill drain via Bennett Brook and Newton Brook into the West Kill, then into Schoharie Creek, the Mohawk River, and, finally, the Hudson River.

Sherrill drains through Peck Hollow into Esopus Creek.

Mount Sherrill is contained within the Westkill Mountain Wilderness Area of New York's Catskill State Park.