[4] In 2019, she appeared along with an actor playing Colonel Sanders in a KFC commercial spoofing a scene from Dirty Dancing, promoting chicken and waffles using Mrs. Butterworth's syrup.

[5][6] In 2020, following protests over systemic racism, Conagra Brands announced that it would review the shape of their bottles, as critics viewed them as an example of the "mammy" stereotype.

[3][8][9] Despite this, some reports had claimed, without citing any sources, that the character was originally modeled on Butterfly McQueen, a black actress who appeared as the maid in Gone with the Wind (1939).

In 2005, Chicago rapper Lupe Fiasco made reference to the brand on Kanye West's "Touch the Sky," with the lyric "bottle-shaped body like Mrs. Butterworth".

[13] In 2013, during episode 12 of the ninth season of Whose Line Is It Anyway?, Ryan Stiles uses comedian Nyima Funk as a bottle of Mrs. Butterworth's to pour onto Colin Mochrie's imaginary waffles during a game of "Living Scenery".