The river flows into the Indian Ocean in an estuary located near Coffee Bay.

The Mthatha river flows in a southeastern direction and is approximately 250 km long with a catchment area of 2,600 km2.

[4] The Mthatha River marks the southern limit of the Pondoland region.

[5] Presently this river is part of the Mzimvubu to Keiskamma Water Management Area.

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