Muckleneuk is a neighborhood located southeast of Pretoria, South Africa.

The name of this area, which includes apartment buildings in the north and various-sized estates in the centre and south, comes from when a parcel of Elandspoort Farm was purchased by George Walker, whose family owned a property in Scotland by that name.

Meaning "big nook", the name was used for three neighbourhoods of Pretoria in succession, including the modern Muckleneuk in 1914.

The quarter's houses include examples of the work of famed architects such as Gerard Moerdijk, Lockwood Hall and Sir Herbert Baker, as well as the Zuid-Afrikaans Hospital, the University of South Africa (UNISA) Art Gallery, Illyria House, and the Portuguese and Egyptian embassies.

Partly situated on a hill, the heights of Muckleneuk provide a panoramic view of the central business district, the Union Buildings and the UNISA campus.