The university's establishment was the result of the 21st meeting of Muhammadiyah Organization of South and South-East Sulawesi Chapters conducted in Bantaeng.
To this day, Muhammadiyah University of Makassar has had seven faculty 34 courses of study and graduate programs that have been accredited by BAN-PT.
Chairman of the Asian Muslim Charity Foundation (AMCF) Dubai, Dr. (HC) Syekh Mohammad MT Al-Khoory.
IMM has the aim of "working towards the formation of Islamic Academics with Noble Morals to achieve Muhammadiyah Goals".
UKM Seni dan Budaya Talas is one of the Student Organizations at Muhammadiyah University of Makassar which is engaged in the arts and culture which was established on September 29, 2000.
Talas has 7 divisions, namely dance, music, design, theater, photos, film, and literature.
UKM Olahraga is one of the Student Organizations at Muhammadiyah University of Makassar which is engaged in sports.
This organization was established on April 3, 2008, known as UBBT (Unit Basket Ball Team) until now it has changed to UKM-Olahraga Unismuh Makassar.
As for several sports in this organization, namely, basketball, football, takraw, futsal, volleyball, table tennis, badminton, chess.
LKIM-PENA was established on December 10, 2005, the Institute for Student Scientific Creativity for Research and Reasoning (LKIM-PENA) was established in the fields of writing such as Research, KTI, Essays, PKM and other written works.
UKM PK Corong which is located at the Blue Campus of the Muhammadiyah University of Makassar was established on 2 September 2000 which was initiated by Brother Muh.
Hizbul Wathan, which is engaged in the scouting sector, which was declared at Unismuh Makassar on November 18, 1999.
Hizbul Wathan is an autonomous organization from Muhammadiyah founded by KH AHMAD DAHLAN in 1918 in Yogyakarta.
Tapak Suci was established on 10 Rabiul Awal 1383 H, or to coincide with July 31, 1963 in Kauman, Yogyakarta.
The Indonesian Red Cross (PMI) Unit 114 Voluntary Corps (KSR) Muhammadiyah University (Unismuh) Makassar.
Rumah Susun Sewa bagi Mahasiswa (Rusunawa) is the dormitory building used for students.
It is stated by the rectore of Unismuh Makassar that Syekh Muhammad Al-Khoory is the one that design this building.
Other facilities in Unismuh campus are: The University of Muhammadiyah Makassar has worked closely with many organizations nationally and internationally.