The Muisne River is a river of Ecuador that enters the Pacific Ocean in the Esmeraldas Province.

It discharges 22 cubic metres per second (780 cu ft/s) into the Pacific.

[1] The low-keyed Muisne resort is in the northern part of the Ensenada de Mompiche, on a 7 kilometres (4.3 mi) sand bar among the mangroves of the Muisne River estuary.

It may be reached by ferry across the Muisne River from the small town of El Relleno.

This article related to a river in Ecuador is a stub.