[10] Doyoyo's honors thesis was on the design and construction of mechanical equipment to investigate false brinelling of heavy-duty bearings in electric motors.

Noting an anomalous behaviour from the experimental observations, he applied the variational perturbation theory to reveal and explain the role played by the increase in mass density during the failure of brittle materials under dynamic compression.

[citation needed] Doyoyo collaborated with researchers in the Joint MIT-Industry Consortium on Ultralight Metal Body Structures, the Cambridge-MIT Institute, and the Next Generation Vehicles Initiative.

[citation needed] The challenge was to come up with new experimental techniques, specimens, and devices to test soft solids under extreme multidimensional crash loads, to simulate a typical collision event.

He developed a trapezoid-shaped specimen to deduce the local stress-strain relation for metal foams to be incorporated into finite element analysis (FEA) codes.

[19] These pressure vessels accommodate non-round shapes resulting in increased safety, driving range, and cabin space for hydrogen vehicles.

As one of the results of this collaboration, he developed Cenocell, a patented concrete-like material that is based on fly ash without the addition of Portland cement.

[21] Fly ash is a pollutant byproduct of coal-fired power plants, cement production, paper manufacturing, and mining operations.

As of 2006, he became interested in doing research aligning with his homeland's Reconstruction and Development Programme (RDP) He started work with his graduate students on green building and renewable energy.

Working in collaboration with concrete manufacturers and mining companies, he developed "green" chemical binders Solunexz and Glunexz for coal dust, construction aggregates, and charcoal.

With continued support from Sasol, he developed Amoriguard, a non-volatile organic compound paint and skim coating based on tailings and industrial waste.