Multipolar spindles

In a mitotic cell wherever two asters convene the formation of a spindle occurs.

[1] Mitosis consists of two independent processes: the intra-chromosomal and the extra-chromosomal (formation of spindle) changes both of these being in total coordination of each other.

In cancer cells, it has been observed that the formation of the spindles comes before when compared to the chromosomes.

The multiple centrosomes segregate to opposite ends of the cell and the spindles attach to the chromosomes haphazardly.

[6] These proteins play a key role in mitosis and are regulated by phosphorylation and degradation.

This cell as seen under immunofluorescence contains four centrosomes, two at each end, with their own spindle fibers attaching to chromosomes at the metaphase plate.
This cell shows chromosomal aberration due to multipolar spindle attachment during metaphase under DAPI staining.