The village of Verkhniye Mully (Ве́рхние Муллы́), one of the oldest historical settlements in the borders of modern Perm, is situated at the banks of the Mulyanka.

[5] Mulyanka is not included in the list of navigable rivers of Perm Krai, which consists of Kama, Vishera, Sylva, and Chusovaya.

The researchers of history of Perm Krai connect it with Tatarian prince Mametkul, who settled in the region before or during the reign of Ivan the Terrible and was an imam, or mullah.

[7][8] In 1722, Georg Wilhelm de Gennin, manager of Ural State Factories and master Cimmerman, took samples of copper ore from the banks of Mulyanka.

[10] According to the results of research, performed by experts of Perm State University, the pollution of Mulyanka exercises strong negative influence on the condition of zoobenthos.

The oil products content of Mulyanka water at the place of the Pyzh's confluence exceeds the Maximum Permissible Concentration 49.4 times.

The chemical analysis of water was performed in the Ecological Laboratory of Chemistry chair in the Perm State Pedagogical University.

[11] In 2005, pupils from the School #59 of Perm City took part in the DOOG—2005 "Remote Educational Contest in Geography" and performed an experiment entitled “Purification of water from the Mulyanka River”.