Jaime I took the Great Mosque or Aljamía to consecrate it to the Virgin Mary; a custom he put in place when he conquered any settlement.

The interior is largely Gothic in style; the facade is Baroque and it was designed by the Valencian architect and sculptor Jaume Bort i Meliá.

The heart and the entrails of King Alfonso X the Wise are buried under the main altar of the cathedral, as he indicated in his testament, as a gift and proof of his love to Murcia and in thanks to the fidelity that the city showed to him.

Under the organ 16th-century plateresque chairs from the Monastery of Santa Maria de Valdeiglesias were installed, a donation made by Queen Isabel II to the cathedral.

The chapels are dedicated to the patron saints of the labour unions and to the burials of the bishops and nobles that helped or collaborated with the construction of the cathedral.