Murder off Miami is a 1987 whodunnit adventure video game based on the book of the same name by British thriller novelist Dennis Wheatley.

Players take the role of Detective Officer Kettering, who is inspecting the supposed suicide of a British financier on a cruise ship in the waters near Miami.

Players progress by collecting clues, interrogating people, and interacting with the environment.

[3] It is based on a novel of the same name by Dennis Wheatley; this text already had some interactivity through the use of physical clues provided with the book such as a blood-stained curtain and cigarette butts, plus an envelope at the end cover to reveal the answer.

[5] Sinclair User thought the game would have used a packaging style similar to that of Weatley's novel.