Murfreesboro High School is an accredited public high school serving students in grades seven through twelve in the rural community of Murfreesboro, Arkansas, United States.

In addition to Murfreesboro, the district, and by extension the high school, also serves Delight, Antoine,[2] Bowen, Billstown, Pike City, and Pisgah.

The assumed course of study follows the Smart Core curriculum developed the Arkansas Department of Education (ADE), which requires students to complete at least 24 credit units before graduation.

The Murfreesboro Rattlers participate in various interscholastic activities in the 2A Classification within the 2A Region 7 (Football) Conference and 2A Region 7 (Basketball) Conference as administered by the Arkansas Activities Association.

The Rattlers school athletic activities include football, basketball (boys/girls), tennis (boys/girls), baseball, softball, and track and field (boys/girls).