The museum was created in 1905 by the mayor of the time, Joseph Reynaud, to receive archaeological collections from Albert Gayet's excavations on the Coptic necropolis of Antinoöpolis, in Egypt.

Soon, Roman and medieval remains of the ancient city of Die (Colonia Dea Augusta Vocontiorum) came to complete the collections of the nascent museum.

A monetary treasure dating from the Wars of Religion soon made its entry (discovered in 1883, he was presented at the communal school).

He traveled the region to study (and if possible, to collect for the museum) the archaeological remains of the past of the city of Die, Luc-en-Diois (the other Roman capital of Vocontii) ) and of this entire Alpine territory of the Drôme.

The museum is planned to be moved to the old episcopal palace of the city (where the mosaic of the four rivers can be seen), which would considerably enlarge its area and add many objects to the current collections.