Vitis rotundifolia, or muscadine,[1] is a grapevine species native to the southeastern and south-central United States.

[4] The plants are well-adapted to their native warm and humid climate; they need fewer chilling hours than better known varieties, and thrive in summer heat.

[6] In a natural setting, muscadine provides wildlife habitat as shelter, browse, and food for many birds and animals.

[13] Unlike most cultivated grapevines, many muscadine cultivars are pistillate, requiring a pollenizer to set fruit.

[12] Muscadine grape cultivars may have low or inconsistent yields, small berries, flavor and thick skin unsuitable to consumer acceptance, and disease susceptibility.

[2] For consumer acceptance, fresh market grapes need to be large, sweet, and with relatively thin skin, whereas those for wine, juice or jelly need high yields of high-sugar, color-stable berries.

[2] Fresh-market cultivars include Black Beauty, Carlos, Cowart, Flowers, Fry, Granny Val, Ison, James, Jumbo, Magnolia, Memory (first found on T.S.

Memory's farm in 1868 in Whiteville, NC), Mish, Nesbitt, Noble, Scuppernong, Summit, Supreme, and Thomas.

[2][13][14] Produced by the University of Florida, the cultivar, 'Southern Home', contains both subgenera Muscadinia and Euvitis (more precisely, V. rotundifolia × V. vinifera) in its background.