The Museo Alameda was the largest Latino museum in the United States and the first formal Smithsonian affiliate outside of Washington D.C., located in the historic Market Square in Downtown San Antonio, Texas.

In May of the same year, Governor George W. Bush signed a joint resolution of the Texas legislature establishing the Museo Alameda as the official State Latino Museum.

Past Exhibitions include: Phantom Sightings: Art After the Chicano Movement (March 2009), American Sabor: Latinos in U.S. Popular Music (June 2009), Escultura Social: A New Generation of Art from Mexico City (July 2008), Myth, Mortals, and Immortality: Works from Museo Soumaya de México (June 2008) and Azucar!

The Museo has also displayed the work of several local San Antonio artists including Alex Rubio and Vincent Valdez in their 2007 exhibition San Anto: Pride of the Southside/En El Mero Hueso (December 2007) and Jesse Treviño in his 2009 exhibition Jesse Treviño: Mi Vida (October 2009).

The roster included: Valerie Aranda, David Blancas, Ruth Buentello, Jose Cosme, Adriana Garcia, Gerry and Cardee Garcia, Jane Madrigal, Cruz Ortiz, Juan Ramos, Israel Rico, Christian Rodriguez, Mike Roman, Alex Rubio, and Enrico Salinas In August 2012, the Museo Alameda announced its impending closure on September 30, 2012, with A&M-San Antonio taking on a new five-year lease; Univision station KWEX-DT also uses the space under a sub-lease as a secondary downtown studio.