[1] A major section is devoted to the Italian Futurists, with works by Giacomo Balla, Umberto Boccioni, Carlo Carrà, Fortunato Depero, Luigi Russolo, Gino Severini, Mario Sironi and Ardengo Soffici.

Giuseppe Pellizza da Volpedo's large canvas Il Quarto Stato (1902) was exhibited in a room on its own,[1] until 2022.

Other sections of the museum are dedicated to individual artists such as Giorgio de Chirico, Lucio Fontana and Morandi.

[1] In 2015 the museum received a large donation from private collectors Bianca and Mario Bertolini of contemporary art works by artists such as Daniel Buren, Joseph Kosuth, Roy Lichtenstein, Robert Rauschenberg, Frank Stella and Andy Warhol.

[2] The museum has a bookshop, and a restaurant-bar on the top floor, overlooking Piazza del Duomo.