The Museum of Motherhood, also known as M.O.M, was conceived in 2003 and first opened to the public on Main St. in Dobbs Ferry, NY with a small exhibition gallery.

was founded under the non-profit Motherhood Foundation Inc. 501c3, and has participated in events throughout New York state, including a village-wide display called "The Moms of Rock" in Seneca Falls, home of the Suffragette Movement (2010), as well as family activities each year at the Museum Mile Festival in New York City.

In 2011, local Gymboree franchise owners Deb Whitefield and Barry Hanson donated a popup museum space in the Yorkville neighborhood of Manhattan's Upper East Side.

An article in the July 2013 issue of the Wall Street Journal[2] addressed the museum's goals of ascribing value to the role of caregiving.

On June 1, 2016, the Museum of Motherhood relocated to an exhibition and teaching space in the Historic Kenwood Artists Enclave at 538 27th St. N. St. Petersburg, Florida 33713.