[3] While she occasionally was identified by some researchers as a daughter of King Artatama I of Mitanni, no evidence proves that she is the same person, and nothing about her own background is known.

[7] He argues that since Mutemwiya was present during the early years of her son's reign, she might have engineered the marriage between Tiye and the young king to connect her family with royalty.

Mutemwiya held many titles including God’s Wife (Hm.t-nTr), Lady of The Two Lands (nb.t-tAwy), Great King’s Wife, his beloved (Hm.t-nsw-wr.t mry.t=f), noblewoman (r.t-pa.t), countess, Great of Praises (wr.t-Hsw.t), Sweet of Love (bnr.t-mrw.t), Mistress of Upper and Lower Egypt (Hnw.t-rsy-mHw), and God's Mother (mwt-nTr).

[10] Mutemwiya is shown in the Luxor temple, in scenes depicting the divine birth of her son Amenhotep III.

In a key scene Mutemwiya is shown seated on a bed receiving the god Amun who had taken the form of her husband Thutmose IV.

The evidence for that is her presence among the sculptures of the Colossi of Memnon, which was built well into his reign, as well as a mention of her estate on a wine-jar label found in Amenhotep III's Malkata palace in Thebes.