The film revolves around TJ "Fuffy" and Amanda "Fream" who are unusually close friends who are often mistaken as a couple.

The cast of My Amanda also includes Luz Valdez, KC Montero, and Helga Krapf.

My Amanda marks as the directorial and writing debut for lead actress Alessandra de Rossi.

[2] The film which took three years to complete, also had Joyce Bernal as its creative producer and Boy Yñiguez as its cinematographer.

[2] Other members of the production team include Marilen Magsaysay (colorist), Kettle Mata (composer), and Hector Calma (assistant director).