It was released as the B-side to "Hey Good Lookin'" in June 1951 on MGM Records.
Williams recorded "My Heart Would Know" on March 16, 1951 at Castle Studio in Nashville with Fred Rose producing.
He was backed on the session by members of his Drifting Cowboys band, including Jerry Rivers (fiddle), Don Helms (steel guitar), Sammy Pruett (electric guitar), Jack Shook (rhythm guitar), Ernie Newton or "Cedric Rainwater," aka Howard Watts (bass), and either Owen Bradley or Rose on piano.
The song begins with an impossibly high steel guitar lick played by Don Helms, which became one of the hallmarks of the Hank Williams sound courtesy of Fred Rose: The song became well known due to the success of the "Hey Good Lookin'" single, which became Williams' sixth number one country hit.
The song later appeared in Disney-Pixar's Cars when McQueen was chased by Sheriff on the way to Radiator Springs.