It depicts the lives of two sisters, one a writer and the other an actress, who move to New York City to further their careers.

Ruth, the more serious and more sensible of the two, aspires to be a writer, while the younger and more attractive Eileen dreams of achieving success as an actress.

The two women find an apartment in a Greenwich Village brownstone owned by Mr. Appopoplous and befriend reporter Chick Adams.

However, the better part of her time is spent supervising Eileen, who has a tendency to fall for every con artist and potential boyfriend who crosses her path while her agent Marty Scott struggles to find her auditions.

[1] In addition to the pilot, 26 episodes — all with Shirley Bonne portraying Eileen — were produced for My Sister Eileen′s run as a regular series on CBS.