Mycale anisochela, the brain sponge, is a species of demosponge from South Africa and Namibia.

It is highly flexible due to its large internal cavities and fibrous skeleton.

The ectosome (the outer region of a sponge) is separated from the choanosome (the inner region) by aquiferous canals that are divided up into more or less regular polygonal areas.

A skeleton of tangential styles, which may be scattered or in bundles, is found in the ectosome.

It is a deep water sponge, found on rocky substrates at depths of 75–351 m (246–1,152 ft).