The Mycetopodidae are a family of freshwater pearly mussels in the order Unionida restricted to South America.

[1][2] They are named for the mushroom-like shape of their foot.

Like all members of the Unionida they reproduce via a larval stage that temporarily parasitizes fish.

Banarescu lists four subfamilies with ten genera in total.

[2] Four subfamilies are recognized.